Boost skin repair, improve elasticity and restore healthy, long-lasting hydration with polynucleotide treatment at our Oxford clinic.
Doctor-led regenerative treatment for tired, crepey or delicate skin at Cannelle Skin Clinic in Oxford
When skin starts to look tired, flat and papery, and creams no longer touch it, the answer is often repair rather than volume. Polynucleotides at Cannelle Skin Clinic in Oxford are made for exactly that. They work at a cellular level, which makes them a strong choice for delicate zones like the under-eyes, as well as the face, neck and hands.
Polynucleotides are injectable chains of highly purified DNA fragments that tell the skin to repair and regenerate itself. They add no volume, unlike a filler. Instead they lift the quality of the skin from the inside, feeding hydration, elasticity and overall skin health.
Because they work with your skin’s own repair machinery, the result arrives gradually and still reads entirely as you. At Cannelle in Oxford, every treatment is planned and carried out by Dr Mattia Parducci, so the approach is shaped around your skin, not a fixed routine.
It is one of our skin booster treatments in Oxford at Cannelle Skin Clinic.
The DNA fragments settle into the skin and act as a repair signal. They wake up fibroblasts, the cells that build collagen and elastin, so the skin steadily becomes healthier, firmer and more resilient.
The result builds as your skin regenerates, which is why polynucleotides are usually given as a short course of one to three sessions a few weeks apart. Tone, texture and elasticity then keep improving over the following weeks.
Dr Mattia starts by examining your skin quality, texture and main concerns. From there he advises how many sessions are likely to help, since polynucleotides tend to work best as a short course rather than a single visit.
Using a fine needle, Dr Mattia places the polynucleotides into the layer of skin that needs support. Delicate zones such as the under-eyes are treated with particular care.
Once settled in the skin, the DNA fragments prompt your fibroblasts to switch into repair mode. This regenerative step is what sets polynucleotides apart from a simple hydrating treatment.
Over the following weeks, those activated cells lay down fresh collagen and elastin. The skin turns firmer, smoother and more elastic, with better tone and resilience.
Completing the recommended course locks in the result, which typically holds for six to twelve months. A maintenance session keeps the regenerative benefit topped up.
Most patients arrive at Cannelle in Oxford when their skin looks tired or crepey and creams have stopped making a difference. From your first consultation through to your follow-up, every step is doctor-led and unhurried, so you always know what comes next.
You meet Dr Mattia for a full skin assessment so he can confirm that polynucleotides are the right call for you. Preparation is simple. Arrive with clean, makeup-free skin and, where you can, avoid blood-thinning supplements for a few days beforehand to reduce the chance of bruising.
Dr Mattia cleanses the skin and applies optional numbing cream for comfort, then injects the polynucleotides into the target area with a fine needle. The session takes around 30 minutes and most patients find it very tolerable.
Small bumps or mild redness at the injection points are normal and usually settle within a day or two. Most patients head back to their normal day straight away. Any further sessions in your course are booked a few weeks apart.
Choosing polynucleotides at Cannelle means a doctor-led treatment where safety, precision and natural results steer every session. Dr Mattia Parducci (GMC 7635663) carries out every treatment himself, so you are never handed to a non-medical injector.
Polynucleotides are injectables, so who treats you matters. At Cannelle, every treatment opens with a proper assessment and is carried out to a medical standard, which keeps the result both safe and natural. If Dr Mattia thinks another skin booster would suit you better, he will tell you honestly.
Polynucleotides at Cannelle Skin Clinic start from £350 per session. They work best as a short course, so many patients choose a package of three sessions, with occasional maintenance after that. Dr Mattia always confirms a clear price at your consultation before anything begins.
Pricing is per session. Most patients choose a package of three for the strongest regenerative result.
| Treatment | Price (£) |
|---|---|
Polynucleotides | 350 |
Polynucleotides are one of several skin-quality boosters we offer in Oxford. Depending on your skin, Dr Mattia may suggest comparing or combining them with Profhilo, PRP or mesotherapy, each of which improves the skin in a slightly different way.
To see how polynucleotides sit alongside our other treatments, and to find the right option for your skin, visit our skin boosters hub or simply book a consultation and let Dr Mattia guide you.
Polynucleotides raise a familiar set of questions from patients in Oxford about cost, comfort, results and suitability. We have answered the most common ones below. If something specific is on your mind, the team is always happy to help, and the clearest answer usually comes from a consultation with Dr Mattia.
Polynucleotides at Cannelle Skin Clinic start from £350 per session, with a recommended course of three at £870. The right plan depends on your skin, so Dr Mattia confirms a clear, itemised price at your consultation before anything begins.
Polynucleotides suit most adults with tired, crepey or dull skin who want genuine repair rather than added volume. Dr Mattia confirms your suitability at a full skin assessment and will point you to an alternative if it would serve you better.
Yes. Polynucleotides are made from highly purified DNA fragments and hold a strong safety record when administered by a qualified doctor. At Cannelle, every treatment is performed by Dr Mattia to a medical standard, which is the single most important safeguard with any injectable.
Most patients notice small bumps at the injection points, with mild redness or tenderness, and these settle within a day or two. The effects are short-lived, and Dr Mattia gives you clear aftercare advice so you know what to expect.
Results typically hold for six to twelve months, depending on your skin and the course you have. Polynucleotides repair the skin gradually, so the effect builds over several weeks rather than appearing overnight. A maintenance session keeps the benefit topped up.
Discomfort is usually minimal. Dr Mattia applies optional numbing cream and uses a fine needle, so most patients describe brief scratches rather than anything painful. Delicate areas such as the under-eyes are treated with extra care.
Most patients have a course of two to three sessions a few weeks apart, since polynucleotides build their effect over time. Skin in good condition may need only one session for a refresh, while more tired or crepey skin benefits from a full course.
Initial freshness can show within a couple of weeks. The fuller result, including improved firmness and texture, develops gradually as new collagen and elastin form and is usually most visible a few weeks after your course.
Polynucleotides are used on the face, neck, décolletage and hands, and are a firm favourite for the delicate under-eye area where skin is thin and crepey. Dr Mattia will recommend the right area or combination at your consultation.
Downtime is minimal. Aside from small bumps and mild redness that settle quickly, most patients return to their normal day straight away. We simply recommend avoiding makeup, heat and strenuous exercise for the first 24 hours.
Once patients grasp what polynucleotides involve, the next questions are usually about how they stack up against Profhilo, fillers and PRP. The answers below cover the comparisons the Cannelle team hears most often about polynucleotides in Oxford.
Weighing regenerative under-eye options? Read Polynucleotides vs PRP for under-eyes.
Both are skin boosters, but they do slightly different jobs. Profhilo deeply hydrates and firms lax skin, while polynucleotides focus on repairing and regenerating tired or delicate skin, such as the under-eyes. The best choice depends on your main concern, so Dr Mattia often recommends one, the other or a combination at your consultation.
The two do very different jobs. Dermal fillers add volume and reshape features, whereas polynucleotides improve the quality of the skin itself: repair, elasticity and texture. Polynucleotides refresh how your skin looks without changing your proportions, and many patients combine the two.
Both are regenerative, but the source differs. PRP uses growth factors from your own blood, while polynucleotides use purified DNA fragments. Both improve skin quality and are sometimes used together. Dr Mattia will advise which suits your skin and goals best.
Yes. Polynucleotides are one of the leading skin boosters, a group of injectable treatments that improve skin quality rather than add volume. To see how they compare with our other options, including Profhilo and PRP, visit our skin boosters hub.
Yes. Many patients at Cannelle combine polynucleotides with Profhilo or other skin boosters, and with dermal fillers where volume is also needed. These treatments complement one another, so Dr Mattia can plan a sequence that suits your skin.
Polynucleotides depend on accurate placement, especially around the delicate under-eye area, so the clinician matters. At Cannelle, every treatment is performed by Dr Mattia Parducci, a qualified doctor, and that is what separates a genuinely effective result from a generic one.
You can book a consultation at Cannelle Skin Clinic in Oxford on WhatsApp, by calling 01865 511960, or by booking online. Our Summertown clinic is easy to reach from across Oxfordshire, including Witney, Bicester, Kidlington and Abingdon.
Year after year, our patients in Oxford return to Cannelle Skin Clinic for natural, healthy-looking results. Every review reflects our commitment to precision, safety and a personalised, doctor-led approach.
Our clinic is located in Summertown, Oxford, just north of the city centre in one of Oxford’s most sought-after neighbourhoods. Discreet and easy to reach, we offer a premium setting for bespoke skin, aesthetic and wellness care.
We welcome patients from across Oxford city and Oxfordshire, including Summertown, Headington, Kidlington, Abingdon, Bicester, Witney and the surrounding towns and villages. Whether you’re coming for routine skin-health treatments or specialist aesthetic consultations, our location is well connected and simple to access.
Our clinic, Cannelle Skin Clinic, is just minutes from Oxford city centre and easily reached by car, bus or rail. Oxford’s mainline stations Oxford Station and Oxford Parkway are a short taxi or bus ride away, and regular services link to London, Reading, Didcot, Banbury and beyond.
By car, we’re conveniently accessed via key local routes with nearby parking options; by public transport, frequent bus routes along Banbury Road drop you within a short stroll of the clinic.
Whether you’re travelling from within Oxfordshire, further afield in the UK or internationally, our clinic offers a calm, personalised and professional environment for your visit.
