Boost skin repair, improve elasticity and restore healthy, long-lasting hydration with polynucleotide treatment at our Oxford clinic.
Doctor-led regenerative skin treatment for tired, crepey or delicate skin at Cannelle Skin Clinic in Oxford
Polynucleotides at Cannelle Skin Clinic in Oxford suit men and women whose skin looks tired, dull or crepey and would benefit from genuine repair rather than added volume. Because they work at a cellular level, they are ideal for delicate areas such as the under-eyes, as well as the face, neck and hands.
Polynucleotides are injectable chains of highly purified DNA fragments that signal the skin to repair and regenerate itself. Rather than adding volume like a filler, they improve the quality of the skin from within, supporting hydration, elasticity and overall skin health.
Because they work with your skin’s own repair process, polynucleotides give a natural, gradual result that still looks entirely like you. At Cannelle in Oxford, every treatment is planned and performed by Dr Mattia Parducci, so the approach is matched to your skin rather than a fixed routine.
It is one of our skin booster treatments in Oxford at Cannelle Skin Clinic.
Polynucleotides work by delivering purified DNA fragments into the skin, where they act as a signal for repair. This stimulates fibroblasts, the cells responsible for producing collagen and elastin, so the skin gradually becomes healthier, firmer and more resilient.
Because the result builds as your skin regenerates, polynucleotides are usually given as a short course of one to three sessions a few weeks apart. The improvement in tone, texture and elasticity then continues to develop over the following weeks.
First, Dr Mattia examines your skin quality, texture and main concerns. He then advises how many sessions are likely to help, as polynucleotides usually work best as a short course rather than a single treatment.
Next, using a fine needle, Dr Mattia injects the polynucleotides into the layer of skin that needs support. Delicate areas such as the under-eyes are treated with particular care.
Once in the skin, the DNA fragments signal your fibroblasts to switch into repair mode. This is the regenerative step that sets polynucleotides apart from a simple hydrating treatment.
Over the following weeks, the stimulated cells produce fresh collagen and elastin. As a result, the skin becomes firmer, smoother and more elastic, with better tone and resilience.
Finally, completing the recommended course consolidates the result, which typically lasts six to twelve months. A maintenance session keeps the regenerative benefit topped up.
Most patients come to Cannelle in Oxford for polynucleotides when their skin looks tired or crepey and creams are no longer enough. From your first consultation through to your follow-up, every step is doctor-led and unhurried, so you always know what to expect.
First, you meet Dr Mattia for a full skin assessment so he can confirm that polynucleotides are right for you. Preparation is simple. Please arrive with clean, makeup-free skin and, where possible, avoid blood-thinning supplements for a few days beforehand to reduce the chance of bruising.
Next, Dr Mattia cleanses the skin and applies optional numbing cream for comfort. He then injects the polynucleotides into the target area using a fine needle. The session takes around 30 minutes and most patients find it very tolerable.
Afterwards, small bumps or mild redness at the injection points are normal and usually settle within a day or two. Most patients return to normal activities the same day. Any further sessions in your course are then booked a few weeks apart.
Choosing polynucleotides at Cannelle means a doctor-led treatment where safety, precision and natural results guide every session. Dr Mattia Parducci (GMC 7635663) performs every treatment personally, so you are never passed to a non-medical injector.
Because polynucleotides are injectables, who treats you matters. At Cannelle, every treatment begins with a proper assessment and is carried out to a medical standard, so the result is both safe and natural. If Dr Mattia feels another skin booster would suit you better, he will say so honestly.
Polynucleotides at Cannelle Skin Clinic start from £350 per session. Because they work best as a short course, many patients choose a package of three sessions, with occasional maintenance after that. Dr Mattia always confirms a clear price at your consultation before anything begins.
Pricing is per session. Most patients choose a package of three for the best regenerative result.
| Treatment | Price (£) |
|---|---|
Polynucleotides | 350 |
Polynucleotides are one of several skin-quality boosters we offer in Oxford. Depending on your skin, Dr Mattia may suggest comparing or combining them with Profhilo, PRP or mesotherapy, each of which improves the skin in a slightly different way.
To see how polynucleotides fit alongside our other treatments, and to find the right option for your skin, visit our skin boosters hub or simply book a consultation and let Dr Mattia guide you.
Polynucleotides raise a familiar set of questions from patients in Oxford about cost, comfort, results and suitability. We have answered the most common ones below. If something specific is on your mind, the team is always happy to help, and the clearest answer often comes from a consultation with Dr Mattia.
Polynucleotides at Cannelle Skin Clinic start from £350 per session, with a recommended course of three at £870. Because the right plan depends on your skin, Dr Mattia confirms a clear, itemised price at your consultation before anything begins.
Polynucleotides suit most adults with tired, crepey or dull skin who want genuine repair rather than added volume. In practice, Dr Mattia confirms your suitability at a full skin assessment and will recommend an alternative if it would serve you better.
Yes. Polynucleotides are made from highly purified DNA fragments and have a strong safety record when administered by a qualified doctor. At Cannelle, every treatment is performed by Dr Mattia to a medical standard, which is the most important safeguard with any injectable.
Most patients notice small bumps at the injection points, along with mild redness or tenderness, which settle within a day or two. In general, these effects are short-lived, and Dr Mattia gives you clear aftercare advice so you know what to expect.
Results typically last six to twelve months, depending on your skin and the course you have. However, because polynucleotides repair the skin gradually, the effect builds over several weeks rather than appearing overnight. A maintenance session keeps the benefit topped up.
Discomfort is usually minimal. Dr Mattia applies optional numbing cream and uses a fine needle, so most patients describe brief scratches rather than anything painful. Delicate areas such as the under-eyes are treated with extra care.
Most patients have a course of two to three sessions a few weeks apart, as polynucleotides build their effect over time. Skin in good condition may need only one session for a refresh, while more tired or crepey skin benefits from a full course.
Initial freshness can appear within a couple of weeks. The fuller result, including improved firmness and texture, develops gradually as new collagen and elastin form and is usually most visible a few weeks after your course.
Polynucleotides are used on the face, neck, décolletage and hands, and are particularly popular for the delicate under-eye area where skin is thin and crepey. Dr Mattia will recommend the right area or combination at your consultation.
Downtime is minimal. Aside from small bumps and mild redness that settle quickly, most patients return to their normal day straight away. We simply recommend avoiding makeup, heat and strenuous exercise for the first 24 hours.
Once patients understand what polynucleotides involve, the next questions are usually about how they compare with Profhilo, fillers and PRP. The answers below cover the comparisons the Cannelle team hears most often about polynucleotides in Oxford.
Both are skin boosters, but they do slightly different jobs. Profhilo deeply hydrates and firms lax skin, while polynucleotides focus on repairing and regenerating tired or delicate skin, such as the under-eyes. Because the best choice depends on your main concern, Dr Mattia often recommends one, the other or a combination at your consultation.
The two do very different jobs. Dermal fillers add volume and reshape features, whereas polynucleotides improve the quality of the skin itself: repair, elasticity and texture. As a result, polynucleotides refresh how your skin looks without changing your proportions, and many patients combine the two.
Both are regenerative, but the source differs. PRP uses growth factors from your own blood, while polynucleotides use purified DNA fragments. Both improve skin quality and are sometimes used together. Dr Mattia will advise which suits your skin and goals best.
Yes. Polynucleotides are one of the leading skin boosters, a group of injectable treatments that improve skin quality rather than add volume. To see how they compare with our other options, including Profhilo and PRP, visit our skin boosters hub.
Yes. Many patients at Cannelle combine polynucleotides with Profhilo or other skin boosters, and with dermal fillers where volume is also needed. Because these treatments complement one another, Dr Mattia can plan a sequence that suits your skin.
Polynucleotides depend on accurate placement, especially around the delicate under-eye area, so the clinician matters. At Cannelle, every treatment is performed by Dr Mattia Parducci, a qualified doctor, which is what separates a genuinely effective result from a generic one.
You can book a consultation at Cannelle Skin Clinic in Oxford on WhatsApp, by calling 01865 511960, or by booking online. Our Summertown clinic is easy to reach from across Oxfordshire, including Witney, Bicester, Kidlington and Abingdon.
Year after year, our patients in Oxford return to Cannelle Skin Clinic for natural, healthy-looking results. Every review reflects our commitment to precision, safety and a personalised, doctor-led approach.
Our clinic is located in Summertown, Oxford, just north of the city centre in one of Oxford’s most sought-after neighbourhoods. Discreet and easy to reach, we offer a premium setting for bespoke skin, aesthetic and wellness care.
We welcome patients from across Oxford city and Oxfordshire, including Summertown, Headington, Kidlington, Abingdon, Bicester, Witney and the surrounding towns and villages. Whether you’re coming for routine skin-health treatments or specialist aesthetic consultations, our location is well connected and simple to access.
Our clinic, Cannelle Skin Clinic, is just minutes from Oxford city centre and easily reached by car, bus or rail. Oxford’s mainline stations Oxford Station and Oxford Parkway are a short taxi or bus ride away, and regular services link to London, Reading, Didcot, Banbury and beyond.
By car, we’re conveniently accessed via key local routes with nearby parking options; by public transport, frequent bus routes along Banbury Road drop you within a short stroll of the clinic.
Whether you’re travelling from within Oxfordshire, further afield in the UK or internationally, our clinic offers a calm, personalised and professional environment for your visit.
