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Doctor-led bio-remodelling treatment for the face, neck and hands at Cannelle Skin Clinic in Oxford
Profhilo at Cannelle Skin Clinic in Oxford suits men and women who notice their skin looking drier, duller or less firm than it used to. Because it improves the quality of the skin rather than adding volume, it is ideal if you want a fresher, healthier complexion without changing the shape of your face.
Profhilo is an injectable treatment made from highly purified hyaluronic acid. Rather than acting as a filler, it spreads through the skin to deeply hydrate it and stimulate your own collagen and elastin. As a result, the skin becomes firmer, smoother and more radiant over a short course of treatment.
Because Profhilo remodels the skin instead of adding volume, it refreshes how your skin looks and feels while keeping your features entirely your own. At Cannelle in Oxford, every treatment is planned and performed by Dr Mattia Parducci, so the approach is matched to your skin rather than a fixed routine.
It is one of our skin booster treatments in Oxford at Cannelle Skin Clinic.

Profhilo works through a process called bio-remodelling. Once injected at five precise points on each side of the face, known as BAP points, it spreads evenly beneath the skin. This deep hydration then stimulates the production of collagen and elastin, so the skin gradually firms and refreshes itself from within.
Because the result builds as your skin regenerates, Profhilo is delivered as a short course. Most patients start with two sessions four weeks apart, after which the improvement in hydration, firmness and glow continues to develop over the following weeks.
First, Dr Mattia identifies the five Bio Aesthetic Points on each side of the face. These positions are chosen so the product spreads safely and evenly, away from blood vessels and nerves.
Next, a small amount of Profhilo is injected at each point. Because it is a free-flowing gel rather than a stiff filler, it begins to disperse through the skin almost immediately.
Once under the skin, Profhilo attracts and holds water, delivering hydration that no cream can reach. As a result, the skin quickly starts to look plumper and more radiant.
Over the following weeks, the hyaluronic acid stimulates new collagen and elastin. This bio-remodelling effect is what firms and tightens the skin from within.
Finally, a second session four weeks later completes the course. The improvement in firmness, texture and glow then continues to build, typically lasting six to nine months.
Most patients come to Cannelle in Oxford for Profhilo when they first notice their skin losing its glow or firmness. From your first consultation through to your follow-up, every step is doctor-led and unhurried, so you always know exactly what to expect.
First, you meet Dr Mattia for a full skin assessment so he can confirm that Profhilo is right for you. Preparation is simple. Please arrive with clean, makeup-free skin and, where possible, avoid blood-thinning supplements such as fish oil for a few days beforehand to reduce the chance of bruising.
Next, Dr Mattia cleanses the skin and applies optional numbing cream for comfort. He then places Profhilo at the five BAP points on each side of the face, using a fine needle. The session itself takes around 20 to 30 minutes and most patients find it very tolerable.
Afterwards, small raised bumps at the injection points are completely normal and usually settle within a day. Mild redness or tenderness can occur but is short-lived, so most patients return to normal activities the same day. Your second session is then booked around four weeks later to complete the course.
Choosing Profhilo at Cannelle means a doctor-led treatment where safety, precision and natural results guide every session. Dr Mattia Parducci (GMC 7635663) performs every treatment personally, so you are never passed to a non-medical injector.
Because Profhilo is an injectable, who treats you matters. At Cannelle, every treatment begins with a proper assessment and is carried out to a medical standard, so the result is both safe and natural. If Dr Mattia feels another skin booster would suit you better, he will say so honestly.

Profhilo at Cannelle Skin Clinic starts from £350 per session. Because the treatment works best as a short course, most patients begin with two sessions four weeks apart, followed by occasional maintenance. Dr Mattia always confirms a clear price at your consultation before anything begins.
Pricing is per session. Most patients begin with a course of two sessions four weeks apart, then maintain with occasional top-ups.
| Treatment | Price (£) |
|---|---|
Profhilo (single session) | £350 |
Profhilo course of 2 (recommended) | £650 |
Profhilo course of 3 | £870 |
Profhilo is one of several skin-quality boosters we offer in Oxford. Depending on your skin, Dr Mattia may suggest comparing or combining it with polynucleotides, PRP or mesotherapy, each of which improves the skin in a slightly different way.
To see how Profhilo fits alongside our other treatments, and to find the right option for your skin, visit our skin boosters hub or simply book a consultation and let Dr Mattia guide you.

Profhilo raises a familiar set of questions from patients in Oxford about cost, comfort, results and suitability. We have answered the most common ones below. If something specific is on your mind, the team is always happy to help, and the clearest answer often comes from a consultation with Dr Mattia.
Profhilo at Cannelle Skin Clinic starts from £350 per session, with a recommended two-session course at £650. Because the right plan depends on your skin, Dr Mattia confirms a clear, itemised price at your consultation before anything begins.
Profhilo suits most adults with dehydrated, dull or early-lax skin who want a natural improvement rather than added volume. In practice, Dr Mattia confirms your suitability at a full skin assessment and will recommend an alternative if it would serve you better.
Yes. Profhilo is made from highly purified hyaluronic acid, a substance found naturally in the skin, and it has a strong safety record when administered by a qualified doctor. At Cannelle, every treatment is performed by Dr Mattia to a medical standard, which is the most important safeguard with any injectable.
Most patients notice small raised bumps at the injection points, which settle within a day, along with mild redness or tenderness. In general, these effects are short-lived, and Dr Mattia gives you clear aftercare advice so you know exactly what to expect.
Results typically last six to nine months, depending on your skin and lifestyle. However, because Profhilo improves the skin gradually, the effect builds over several weeks rather than appearing overnight. A maintenance session once or twice a year keeps your skin looking its best.
Discomfort is usually minimal. Dr Mattia applies optional numbing cream and uses a fine needle at a small number of points, so most patients describe brief scratches rather than anything painful. The session is quick, which keeps it comfortable.
For the best result, yes. Profhilo is designed as a course, and two sessions four weeks apart give the skin the hydration and collagen stimulation it needs to firm and glow. After that, a single maintenance session is usually enough to keep the result going.
Initial hydration and glow can appear within a couple of weeks. The fuller result, including firmer, smoother skin, develops gradually as new collagen forms and is usually most visible a few weeks after your second session.
Profhilo is most commonly used on the face, but it also works beautifully on the neck, décolletage and the backs of the hands, where skin often looks crepey or dehydrated. Dr Mattia will recommend the right area or combination at your consultation.
Downtime is minimal. Aside from small bumps and mild redness that settle quickly, most patients return to their normal day straight away. We simply recommend avoiding makeup, heat and strenuous exercise for the first 24 hours.
Once patients understand what Profhilo involves, the next questions are usually about how it compares with fillers, polynucleotides and other skin boosters. The answers below cover the comparisons the Cannelle team hears most often about Profhilo in Oxford.
The two do very different jobs. Dermal fillers add volume and reshape features such as the lips or cheeks, whereas Profhilo improves the quality of the skin itself: hydration, firmness and glow. As a result, Profhilo refreshes how your skin looks without changing your proportions, and many patients combine the two for a complete result.
Both are skin boosters, but they work differently. Profhilo deeply hydrates and firms lax skin, while polynucleotides focus on repairing and regenerating tired or delicate skin, such as the under-eye area. Because the best choice depends on your main concern, Dr Mattia often recommends one, the other or a combination at your consultation.
Yes. Profhilo is one of the best known skin boosters, a group of injectable treatments that improve skin quality rather than add volume. To see how it compares with our other options, including polynucleotides and PRP, visit our skin boosters hub.
Yes. Many patients at Cannelle combine Profhilo with dermal fillers for volume, or with other skin boosters for an all-round result. Because these treatments complement one another, Dr Mattia can plan a sequence that suits your skin and your timescale.
For patients who want healthier, firmer and more hydrated skin without filler or downtime, Profhilo offers strong value. A short two-session course delivers a natural improvement that lasts several months, and the result can be maintained with a single top-up session each year.
Profhilo depends on correct placement and an honest assessment of whether it is the right treatment for you, so the clinician matters. At Cannelle, every treatment is performed by Dr Mattia Parducci, a qualified doctor, which is what separates a genuinely effective result from a generic one.
You can book a consultation at Cannelle Skin Clinic in Oxford on WhatsApp, by calling 01865 511960, or by booking online. Our Summertown clinic is easy to reach from across Oxfordshire, including Witney, Bicester, Kidlington and Abingdon.
Year after year, our patients in Oxford return to Cannelle Skin Clinic for natural, healthy-looking results. Every review reflects our commitment to precision, safety and a personalised, doctor-led approach.
Our clinic is located in Summertown, Oxford, just north of the city centre in one of Oxford’s most sought-after neighbourhoods. Discreet and easy to reach, we offer a premium setting for bespoke skin, aesthetic and wellness care.
We welcome patients from across Oxford city and Oxfordshire, including Summertown, Headington, Kidlington, Abingdon, Bicester, Witney and the surrounding towns and villages. Whether you’re coming for routine skin-health treatments or specialist aesthetic consultations, our location is well connected and simple to access.
Our clinic, Cannelle Skin Clinic, is just minutes from Oxford city centre and easily reached by car, bus or rail. Oxford’s mainline stations Oxford Station and Oxford Parkway are a short taxi or bus ride away, and regular services link to London, Reading, Didcot, Banbury and beyond.
By car, we’re conveniently accessed via key local routes with nearby parking options; by public transport, frequent bus routes along Banbury Road drop you within a short stroll of the clinic.
Whether you’re travelling from within Oxfordshire, further afield in the UK or internationally, our clinic offers a calm, personalised and professional environment for your visit.